![]() Already within the first week there was a highly significant decrease of nights with leg cramps within the CTED group (n = 34) from 4.68 (95% confidential interval 2.26-7.0) to 2.25 (0-6.78) in comparison to placebo (n = 40 from 4.32 to 3.69 ) and quinine (n = 43 from 4.78 to 3.27 F-test p = 0.0001 resp. In 117 patients an analysis of the time course of the efficacy could be done from the notes in the diary (minimum duration of treatment 11 d). 39.5% of the cases p less than 0.001 x-test). The global efficacy judged by the physicians and investigated for the 126 patients who took the compounds at least four days within the random phase was remarkably better for the combination than for quinine or placebo (very good and good in 87.1 vs. The subsequent 2 weeks were carried out double-blind. In the first week all patients were treated in a single blind design with placebo. The duration of the study was three weeks. If recurrences of cramp after treatment ended. Only patients who suffered before the begin of the study in at least three nights per week from leg cramps were included. One trial of 150 women comparing sodium chloride with placebo (Robinson 1947) showed a possible reduction in leg cramps: 13 of 57 women given placebo were unchanged or their cramps recurred, compared with 13 of 93 women given sodium chloride, (odds ratio 0.54, 95 confidence interval 0.23 to 1.29). Light exercise, such as riding a stationary bicycle for a few minutes before bedtime, also may help prevent cramps while you sleep.164 patients (m = 45, w = 119 age 55.7 +/- 14.7 years) took part in a multicentric controlled parallel-double blind study in which efficacy and tolerability of the combination quinine sulfate (CAS ) plus theophylline ethylene diamine (CTED, CAS 317-34-0) (Limptar) in the treatment of the recurrent nocturnal leg cramps were investigated. To avoid getting leg cramps at night, stretch before bedtime. ![]() Stretch gently before and after using any muscle for a time. Keep drinking water or other liquids without caffeine or alcohol after the activity. During activity, drink liquids regularly. Being overweight can increase the risk of muscle cramps. Having diabetes or illnesses that involve nerves, liver or thyroid can increase the risk of muscle cramps. Muscle cramps are common during pregnancy. Factors that may lead to leg cramps attacks include hemodialysis, electrolyte imbalance, metabolic disorders, and congenital disorders. ![]() Athletes who get tired and sweat a lot while playing sports in warm weather often get muscle cramps. The medical history and physical examination are usually sufficient to differentiate nocturnal leg cramps from other conditions, such as restless legs syndrome, claudication, myositis, and peripheral neuropathy. Not being in shape for an activity causes muscles to tire more easily. Then the muscles can't work as hard and can get stressed more easily. Medicines often prescribed for high blood pressure can cause increased urination, which may drain the body of these minerals.įactors that might increase the risk of muscle cramps include: Too little potassium, calcium or magnesium in the diet can cause leg cramps. Walking bent slightly forward, such as when pushing a shopping cart, might ease cramping. ![]() The pain usually gets worse with walking. Pressure on the nerves in the spine also can cause cramping pain in the legs. These cramps usually go away soon after exercise stops. A narrowing of the arteries that bring blood to the legs can cause a cramping pain in the legs and feet during exercise. But some might be related to a medical concern, such as: A muscle cramp can happen after working a muscle too hard or straining it, losing body fluids through sweat or simply holding a position for a long time.
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